Dr. Carlisle's research interests focus on lung diseases caused by second-hand smoke, and developing novel therapies, particularly stem cell therapies, for these diseases. One area of emphasis for her current research is on chronic obstructive pulmonary disease (COPD), including emphysema. COPD is characterized by a loss of the specialized cells of the lungs that exchange air, and the fibrosis that follows. There is currently no treatment for this debilitating disease, which compromises the ability of the COPD patient to breathe, even with oxygen. Dr. Carlisle has underway a project looking at the use of stem cells to investigate the pathology of COPD to further our understanding of the causes of the disease. In addition, she is investigating the potential of stem cells as a therapy for COPD.
Dr. Carlisle is funded by the Flight Attendant Medical Research Institute, a foundation focused on funding research into cures for diseases caused by second-hand smoke.
Selected Publications
Liu X, Carlisle D.L., Swick M.C., Gaither-Davis A, Grandis J.R., Siegfried J.M. Gastrin-releasing peptide activates Akt through the epidermal growth factor
receptor pathway and abrogates the effect of gefitinib. Exp Cell Res. 2007 Apr 15;313(7):1361-72.
Carlisle D.L., Liu X, Hopkins T.M., Swick M.C., Dhir R, Siegfried J.M. Nicotine activates cell-signaling pathways through muscle-type and neuronal
nicotinic acetylcholine receptors in non-small cell lung cancer cells. Pulm Pharmacol Ther. 2006 Aug 18.
Carlisle, D.L., Hopkins, T.M., Gaither-Davis, A., Silhanek, M.J., Luketich, J.D., Christie, N., Siegfried, J.M. (2004) Nicotine signals through muscle-type and neuronal nicotinic acetylcholine receptors in both human bronchial epithelial cells and airway fibroblasts. Res. Research. 5(27)1-16.
Carlisle, D.L., Devereux, W.L., Hacker, A., Woster, P.M., and Casero,Jr, R.A. (2002) Growth status significantly affect the response of human lung cancer cells to anitiumor polyamine analogue exposure. Clin, Can. Res. 8(8):2684-9.
Carlisle, D.L., Pritchard, D.E., Singh, J. Owens, B.M., Blankenship, L.J., Orenstein, J.M, and Patierno, S.R. (2000). Apoptosis and p53 induction in human lung fibroblasts exposed to chromium (VI): effect of ascorbate and tocopherol. Tox. Sci. 55, 60-8.
Carlisle, D. L., Pritchard, D. E., Singh, J., and Patierno, S. R. (2000). Chromium(VI) induces p53-dependent apoptosis in diploid human lung and mouse dermal fibroblasts. Molecular Carcinogenesis 28, 111-8.
Pritchard, D.E., Singh, J., Carlisle, D.L., and Patierno, S.R. (2000). Cyclosporin A inhibits chromium (VI)-induced apoptosis and mitochondrial cytochrome C release and restores clonogenic survival in CHO cells. Carcinogenesis 11:2027-33.
Complete
Publication Listing
Professional Affiliations
American Association for Cancer Research
Women in Cancer Research
Diane Carlisle, Ph.D.