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Gerald P. Schatten, Director of the Pittsburgh Development Center Diane Carlisle Carlos A. Castro
Kyle Orwig Cal Simerly
Laura Hewitson, Ph.D.

        

Dr. Calvin SimerlyCalvin R. Simerly, Ph.D.

Assistant Investigator, Magee-Womens Research Institute
Associate Professor of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh
Faculty Member, Pittsburgh Development Center

Ph.D., University of Wisconsin-Madison, 1998

Research Interests

The research of Dr. Simerly and colleagues converges on understanding human reproduction and development through discoveries on the cellular and molecular basis of fertilization and early development. Using primates and other systems we address questions in:

  • The cytoskeleton during fertilization (e.g. microtubules, microfilament and chromosome configurations during meiosis, fertilization, early development)
  • The centrosome during fertilization (e.g. inheritance, molecular constituents, defects in male and female gametes leading to infertility)
  • Molecular motors in meiosis, fertilization and early development (kinesins, dyneins, myosins and NuMA in meiotic and mitotic spindle formationpronuclear apposition; chromosome positioning)
  • Epigenetic modifications in male and female gametes (DNA methylation, acetylation and imprinting in androgenotes, gynogenotes and chimeric embryos in nonhuman primates)
  • Cellular basis of cloning after nuclear transfer (microtubule, centrosome inheritance; mitotic spindle formation; cleavage events; epigenetic modifications during nuclear reprogramming)
  • Cloned transgenic disease models (dynamic noninvasive imaging of transgenic reporters; immunocytochemical detection of integrated transgene reporters)
  • Stem cell biology (ES cells derived from fertilized and parthenogenetic blastocyst; centrosome biology of stem cells; DNA epigenetic events)

Recent Publications

Navara CS, Mich-Basso JD, Redinger CJ, Ben-Yehudah A, Jacoby E, Kovkarova-Naumovski E, Orwig K, Kaminski N, Castro CA, Simerly CR, Schatten G. Pedigreed Primate Embryonic Stem Cells Express Homogeneous Familial Gene Profiles. Stem Cells, in press.(2007)

Sánchez-Partifa LG, Simerly CR, Ramalho-Santos J. Freeze-Dried Primate Sperm Retains Early Putative Reproductive Potential After Intracytoplasmic Sperm Injection (ICSI). Fert Steril, in press. (2007).

Simerly C and Navara, CS. The Sperm Centriole: Its effect on the developing embryo. In: Human Embryo Evaluation and Selection (ed. J. Cohen, K. Elder) in press. Taylor & Francis Group, Oxford, UK (2007)

St John JC , Ramalho-Santos J, Gray HL, Petrosko P, Rawe VY, Navara CS, Simerly CR, Schatten GP. The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells. Cloning Stem Cells 7(3):141-53 (2005).

Simerly C, Navara CS, Hyun SH, Lee BC, Kang SK, Capuano S, Gosman G, Dominko T, Chong K-Y, Compton D., Hwang WS, & Schatten, G. . Embryogenesis and blastocyst development after somatic cell nuclear transfer in nonhuman primates: overcoming defects caused by meiotic spindle extraction. Dev Biol 276: 237– 252 (2004).

Simerly C, Dominko T, Navara C, Payne C, Capuano S, Gosman G, Chon, KY, Takahashi D, Chace C, Compton D, Hewitson L, and Schatten G. Molecular Correlates of Primate Nuclear Transfer Failures. Science 300: 297 (2003).

Complete Publication Listing


Professional Affiliations

American Society of Cell Biology


 
 

Last Modified: 19-Sep-2008
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